The primary purpose of this research work was to prepare a gastroretentive drug delivery system of lansoprazole. Formulation trials were carried out using natural and synthetic swelling polymers like guar gum, xanthan gum and HPMC K4M for ascertaining the best possible polymer for further studies. The effects of citric acid and stearic acid on drug release profile and floating properties were also investigated. The addition of stearic acid reduced the drug dissolution due to its hydrophobic nature. Among the three polymers HPMC K4M showed better results and found to be suitable for floating delivery device. The amount of HPMC K4M and stearic acid were found to significantly influence all in-vitro response parameters. So, optimization was carried out by using central composite design by taking HPMC K4M and stearic acid as independent variables and floating lag time, % drug release for 3 h, % drug release for 8 h as dependent variables respectively. The optimized formulation released 92 % drug release upto 8 h. The swelling index in 5 h and floating lag time were found to be 56 % and 9 sec respectively. The results of pre-compression and post-compression parameters of all the formulations were found to be within the limits. Accelerated stability studies of the optimized formulation indicated no appreciable change in the drug content and in-vitro drug release rates of formulation. Thus, with using optimum concentrations of HPMC K4M and stearic acid the floating tablet of lansoprazole was successfully developed for sustained action.
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